Object structure

Creator:

Walicka, Anna ; Iwanowska-Chomiak, Beata

Contributor:

Jurczak, Paweł - red.

Title:

Fractal model of transdermal drug delivery

Group publication title:

IJAME, volume 23 (2018)

Subject and Keywords:

drug delivery ; human skin ; epidermis ; fractal models

Abstract:

Skin, separating the vital organs of a human body, is a desirable route for drug delivery. However, the intact skin is normally permeable only for drug molecules with a low molecular weight. The stratum corneum (SC), being the outermost layer of the skin and the epidermis being the second - more permeable - layer of the skin, play an essential function in transdermal drug delivery. Physical and chemical methods of skin poration are used to enhance transdermal drug delivery. ; Each poration leads to an irregular system of pores which are connected with a system of micro-capillaries passing through the epidermis. Both the systems by their irregularity form a fractal porous matrix. Drugs administrated by this matrix can be either suspensions and solutions or creams and gels, therefore they have to be modelled as non-Newtonian fluids. To analyse the fluid flow through the porous matrix the model of the epidermis is assumed as gobbet-and-mortar with the tortuous mortar of variable thickness and after transition from the mortar to the tube one considered classical and fractal capillary flows of selected non-Newtonian fluids. ; Fractal expressions for the flow rate, velocity and permeability of fluids flow in a porous matrix are derived based on the fractal properties of the epidermis and capillary model. Each parameter in the proposed expressions does not contain any empirical constant and has a clear physical meaning and the proposed fractal models relate the flow properties of considered fluids with the structural parameters of the epidermis as a porous medium. The presented analytical expressions will help understand some of the physical principles of transdermal drug delivery.

Publisher:

Zielona Góra: Uniwersytet Zielonogórski

Date:

2018

Resource Type:

artykuł

Format:

application/pdf

DOI:

10.2478/ijame-2018-0056

Pages:

989-1004

Source:

IJAME, volume 23, number 4 (2018)

Language:

eng

License:

CC 4.0

License CC BY-NC-ND 4.0:

click here to follow the link

Rights:

Biblioteka Uniwersytetu Zielonogórskiego