Object
Title: Drug diffusion transport through human skin
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Abstract:
The stratum corneum (SC) forms the outermost layer of the human skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment membrane integrity and significantly increase membrane tortuosity. The lipophilic character of the SC, coupled with its intrinsic tortuosity, ensure that it almost always provides the principal barrier to the entry of drug molecules into the organism. ; Drugs can be administered either as suspensions or as solutions and the formulation can range in complexity from a gel or and ointment to a multilayer transdermal path. In this paper, we discuss theoretical principles used to describe transdermal release and we show that relatively simple membrane transport models based on the appropriate solution to the Fick`s second law of diffusion can be used to explain drug release kinetics into such a complex biological membrane as the human skin. ; To apply the Fick`s law we introduced into our considerations a brick-and-mortar model with two factors of tortuosity. Assuming that the mortar thickness is variable we also introduced the hindrance factor allowing us to model this variability. Having the modified Fick`s equation we presented its general solution and two special cases of this solution frequently applicable in permeation experiments. It seems that the solutions presented herein better approximate the real conditions of drug delivery then these well known.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
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Pages:
Source:
IJAME, volume 23, number 4 (2018)
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License CC BY-NC-ND 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Repository > Faculties > Faculty of Mechanical Engineering
- Repository > Types of work > Articles
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mechanics and Engineering (IJAME)
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mechanics and Engineering (IJAME) > International Journal of Applied Mechanics and Engineering (IJAME) (2018)
Last modified:
Jul 6, 2023
In our library since:
Apr 4, 2023
Number of object content hits:
99
All available object's versions:
https://zbc.uz.zgora.pl/repozytorium/publication/80193
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International Journal of Applied Mechanics and Engineering (IJAME)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 2 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 3 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018)
- International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018) - spis treści
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
| Edition name | Date |
|---|---|
| Drug diffusion transport through human skin | Jul 6, 2023 |
