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Title: Quality improvement of rule-based gene group descriptions using information about GO terms importance occurring in premises of determined rules

Creator:

Sikora, Marek ; Gruca, Aleksandra

Date:

2010

Resource Type:

artykuł

Contributor:

Korbicz, Józef - red. ; Uciński, Dariusz - red.

Group publication title:

AMCS, Volume 20 (2010)

Abstract:

In this paper we present a method for evaluating the importance of GO terms which compose multi-attribute rules. The rules are generated for the purpose of biological interpretation of gene groups. Each multi-attribute rule is a combination of GO terms and, based on relationships among them, one can obtain a functional description of gene groups. We present a method which allows evaluating the influence of a given GO term on the quality of a rule and the quality of a whole set of rules ; For each GO term, we compute how big its influence on the quality of generated set of rules and therefore the quality of the obtained description is. Based on the computed quality of GO terms, we propose a new algorithm of rule induction in order to obtain a more synthetic and more accurate description of gene groups than the description obtained by initially determined rules. The obtained GO terms ranking and newly obtained rules provide additional information about the biological function of genes that compose the analyzed group of genes.

Publisher:

Zielona Góra: Uniwersytet Zielonogórski

Resource Identifier:

oai:zbc.uz.zgora.pl:46873

DOI:

10.2478/v10006-010-0041-3

Pages:

555-570

Source:

AMCS, Volume 20, Number 3 (2010) ; click here to follow the link

Language:

eng

Rights:

Biblioteka Uniwersytetu Zielonogórskiego

Subject and keywords:

decision rules importance of rules premises measures of rules interestingness gene ontology descriptions of gene groups

Object collections:

Last modified:

Sep 7, 2021

In our library since:

Aug 14, 2018

Number of object content hits:

125

All available object's versions:

https://zbc.uz.zgora.pl/publication/54968

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Quality improvement of rule-based gene group descriptions using information about GO terms importance occurring in premises of determined rules Sep 7, 2021

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Phone

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E-Mail

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65-077 Zielona Góra

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