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Title: Response of Lyapunov exponents to diffusion state of biological networks

Współtwórca:

Korbicz, Józef (1951- ) - red. ; Uciński, Dariusz - red.

Tytuł publikacji grupowej:

AMCS, volume 30 (2020)

Abstract:

The topologies of protein-protein interaction networks are uncertain and noisy. The network topology determines the reliability of computational knowledge acquired from noisy networks and can impose the deterministic and non-deterministic character of the resulting data. In this study, we analyze the effect of the network topology on Lyapunov exponents and its relationship with network stability. ; We define the methodology to convert the network data into signal data and obtain the Lyapunov exponents for a variety of networks. We then compare the Lyapunov exponent response and the stability results. Our technique can be applied to all types of network topologies as demonstrated with our experiments, conducted on both synthetic and real networks from public databases. For the first time, this article presents findings where Lyapunov exponents are evaluated under topological mutations and used for network analysis. ; Experimental results show that Lyapunov exponents have a strong correlation with network stability and both are correlatively affected by the network model. Hence we develop a novel coefficient, termed LEC, to measure the robustness of biological networks. LEC can be applied to real or synthetic biological networks rapidly. Results are a striking indication that the Lyapunov exponent is a potential candidate measure for network analysis.

Wydawca:

Zielona Góra: Uniwersytet Zielonogórski

Identyfikator zasobu:

oai:zbc.uz.zgora.pl:86182

DOI:

10.34768/amcs-2020-0051

Strony:

689-702

Źródło:

AMCS, volume 30, number 4 (2020) ; click here to follow the link

Jezyk:

eng

Licencja CC BY 4.0:

click here to follow the link

Prawa do dysponowania publikacją:

Biblioteka Uniwersytetu Zielonogórskiego

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