Digital Library of Zielona Góra contains 9 272 digital objects
Object
Title: Model based analysis of signaling pathways
Contributor:
Kasiński, Andrzej - ed. ; Ponulak, Filip - ed.
Subtitle:
Group publication title:
Abstract:
The paper is concerned with application of mathematical modeling to the analysis of signaling pathways. Two issues, deterministic modeling of gene transcription and model-driven discovery of regulatory elements, are dealt with. First, the biological background is given and the importance of the stochastic nature of biological processes is addressed. The assumptions underlying deterministic modeling are presented. Special emphasis is put on describing gene transcription. ; A framework for including unknown processes activating gene transcription by means of first-order lag elements is introduced and discussed. Then, a particular interferon-? induced pathway is introduced, limited to early events that precede activation of gene transcription. It is shown how to simplify the system description based on the goals of modeling. Further, a computational analysis is presented, facilitating better understanding of the mechanisms underlying regulation of key components in the pathway. The analysis is illustrated by a comparison of simulation and experimental data.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
Resource Identifier:
DOI:
Pages:
Source:
AMCS, volume 18, number 2 (2008) ; click here to follow the link
Language:
License CC BY 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Repository > Faculties > Faculty of Computer, Electrical and Control Engineering
- Repository > Types of work > Articles
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS) > International Journal of Applied Mathematics and Computer Science (AMCS) (2008)
Last modified:
Jul 14, 2025
In our library since:
Apr 5, 2024
Number of object content hits:
101
All available object's versions:
https://zbc.uz.zgora.pl/repozytorium/publication/88465
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 18, number 1 (2008)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 18, number 2 (2008)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 18, number 3 (2008)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 18, number 4 (2008)
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| Edition name | Date |
|---|---|
| Model based analysis of signaling pathways | Jul 14, 2025 |
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