Digital Library of Zielona Góra contains 9 272 digital objects
Object
Title: Coupled analytical and numerical approach to uncovering new regulatory mechanisms of intracellular processes
Contributor:
Korbicz, Józef (1951- ) - red. ; Uciński, Dariusz - red.
Group publication title:
Abstract:
The paper deals with the analysis of signaling pathways aimed at uncovering new regulatory processes regulating cell responses. First, general issues of comparing simulation and experimental data are discussed, and various aspects of data normalization are covered. Then, a model of a particular signaling pathway, induced by Interferon-?, is briefly introduced. It serves as an example illustrating how mathematical modeling can be used for inferring the structure of a regulatory system governing the dynamics of intracellular processes. ; In this pathway, experimental results suggest that a hitherto unknown process is responsible for a decrease in the levels of one of the important molecules used in the pathway. Then, equilibrium points of the model are analyzed, allowing the rejection of all but one explanation of the phenomena observed experimentally. Numerical simulations confirm that the model can mimic the dynamics of the processes in the pathway under consideration. Finally, some remarks about the applicability of the method based on an analysis of equilibrium points are made.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
Resource Identifier:
DOI:
Pages:
Source:
AMCS, Volume 20, Number 4 (2010) ; click here to follow the link
Language:
License CC BY 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Repository > Faculties > Faculty of Computer, Electrical and Control Engineering
- Repository > Types of work > Articles
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS) > International Journal of Applied Mathematics and Computer Science (AMCS) (2010)
Last modified:
Jul 14, 2025
In our library since:
Aug 16, 2018
Number of object content hits:
246
All available object's versions:
https://zbc.uz.zgora.pl/repozytorium/publication/54989
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 20, number 1 (2010)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 20, number 2 (2010)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 20, number 3 (2010)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 20, number 4 (2010)
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| Edition name | Date |
|---|---|
| Coupled analytical and numerical approach to uncovering new regulatory mechanisms of intracellular processes | Jul 14, 2025 |
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