Object
Title: Regulation of p53 by siRNA in radiation treated cells: Simulation studies
Contributor:
Cordón, Oskar - ed. ; Kazienko, Przemysław - ed.
Subtitle:
Hybrid and Ensemble Methods in Machine Learning
Group publication title:
Abstract:
Ionizing radiation activates a large variety of intracellular mechanisms responsible for maintaining appropriate cell functionality or activation of apoptosis which eliminates damaged cells from the population. The mechanism of such induced cellular death is widely used in radiotherapy in order to eliminate cancer cells, although in some cases it is highly limited by increased cellular radio-resistance due to aberrations in molecular regulation mechanisms of malignant cells. ; Despite the positive correlation between the radiation dose and the number of apoptotic cancer cells, radiation has to be limited because of extensive side effects. Therefore, additional control signals whose role will be to maximize the cancer cells death-ratio while minimizing the radiation dose and by that the potential side effects are worth considering. ; In this work we present the results of simulation studies showing possibilities of single gene regulation by "small interfering RNA" (siRNA) that can increase radio-sensitivity of malignant cells showing aberrations in the p53 signaling pathway, responsible for DNA damage-dependant apoptosis. By blocking the production of the p53 inhibitor Mdm2, radiation treated cancer cells are pushed into the apoptotic state on a level normally achievable only with high radiation doses. ; The presented approach, based on a simulation study originating from experimentally validated regulatory events, concerns one of the basic problems of radiotherapy dosage limitations, which, as will be shown, can be partially avoided by using the appropriate siRNA based control mechanism.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
Resource Identifier:
DOI:
Pages:
Source:
AMCS, Volume 22, Number 4 (2012) ; click here to follow the link
Language:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Digital Library of Zielona Góra > Repository > Faculties > Faculty of Computer, Electrical and Control Engineering
- Digital Library of Zielona Góra > Repository > Types of work > Articles
- Digital Library of Zielona Góra > Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS) > International Journal of Applied Mathematics and Computer Science (AMCS) (2012)
Last modified:
Oct 18, 2022
In our library since:
Sep 15, 2021
Number of object content hits:
154
All available object's versions:
https://zbc.uz.zgora.pl/publication/65825
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International Journal of Applied Mathematics and Computer Science (AMCS)
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| Edition name | Date |
|---|---|
| Regulation of p53 by siRNA in radiation treated cells: Simulation studies | Oct 18, 2022 |
