Digital Library of Zielona Góra contains 9 272 digital objects
Object
Title: On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: Insights from a mathematical model
Creator:
Bodnar, Marek ; Foryś, Urszula ; Piotrowska, Monika J. ; Bodzioch, Mariusz ; Romero-Rosales, Jose A. ; Belmonte-Beitia, Juan
Date:
Resource Type:
Contributor:
Foryś, Urszula - ed. ; Rejniak, Katarzyna - ed. ; Pękala, Barbara - ed. ; Bartłomiejczyk, Agnieszka - ed.
Subtitle:
Group publication title:
Abstract_pl:
Chimeric antigen receptor T (CAR-T) cell therapy has been proven to be successful against different leukaemias and lymphomas. Its success has led, in recent years, to its use being tested for different solid tumours, including glioblastoma, a type of primary brain tumour, characterised by aggressiveness and recurrence. This paper presents an analytical study of a mathematical model describing the competition of CAR-T and glioblastoma tumour cells, taking into account their immunosuppressive capacity. ; The model is formulated in a general way, and its basic properties are investigated. However, most of the analysis considers the model with exponential tumour growth, assuming this growth type for simplicity. The existence and stability of steady states are studied, and the subsequent focus is on two different types of treatment: constant and periodic. Finally, protocols for CAR-T cell therapy of glioblastoma are numerically derived; these are aimed at preventing the tumour from reaching a critical size and at prolonging the patients` survival time as much as possible. The analytical and numerical results provide theoretical support for the treatment of glioblastoma using CAR-T cells.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
Resource Identifier:
DOI:
Pages:
Source:
AMCS, volume 33, number 3 (2023) ; click here to follow the link
Language:
License CC BY 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Repository > Faculties > Faculty of Computer, Electrical and Control Engineering
- Repository > Types of work > Articles
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS) > International Journal of Applied Mathematics and Computer Science (AMCS) (2023)
Last modified:
Jul 25, 2025
In our library since:
Jul 25, 2025
Number of object content hits:
12
All available object's versions:
https://zbc.uz.zgora.pl/repozytorium/publication/101597
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 33, number 1 (2023)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 33, number 2 (2023)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 33, number 3 (2023)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 33, number 4 (2023)
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| Edition name | Date |
|---|---|
| On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: Insights from a mathematical model | Jul 25, 2025 |
Objects Similar
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Bartłomiejczyk, Agnieszka Bodnar, Marek Bogdańska, Magdalena U. Piotrowska, Monika J. Korbicz, Józef (1951- ) - red. Uciński, Dariusz - red.
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Kapliński, Oleg Świtka, Romuald - red.
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