Object
Title: Neural network signal interpretation for optimization of chromatographic protein purifications
Contributor:
Skliar, Mikhail - red. ; Ramirez, W. Fred - red.
Subtitle:
Data Processing and Process Control
Group publication title:
Abstract:
Mobile phase pH and salt gradient steepness are optimized for the separation of protein mixtures using gradient elution ion-exchange chromatography. The optimization method utilizes a factorial experimental design to generate an experimental matrix. The resulting chromatographic peaks are classified into six distinct classes based on peak geometry by a vector quantizing neural network (VQN). ; A modified chromatographic optimization function (COF), which accounts for the neural net classification as well as peak separation and total analysis time, is used to rank chromatograms in order of desirability. Results of the COF analysis are fit to a second order polynomial model, which is optimized in the experimental parameters using an advanced simplex algorithm.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
Resource Identifier:
Pages:
Source:
AMCS, volume 8, number 4 (1998) ; click here to follow the link
Language:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Repository > Faculties > Faculty of Computer, Electrical and Control Engineering
- Repository > Types of work > Articles
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS)
- Repository > Scientific journals and UZ publishing series > International Journal of Applied Mathematics and Computer Science (AMCS) > International Journal of Applied Mathematics and Computer Science (AMCS) (1998)
Last modified:
Sep 3, 2021
In our library since:
Dec 22, 2020
Number of object content hits:
50
All available object's versions:
https://zbc.uz.zgora.pl/repozytorium/publication/64679
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International Journal of Applied Mathematics and Computer Science (AMCS)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 26 (2016)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 25 (2015)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 24 (2014)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 23 (2013)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 22 (2012)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 21 (2011)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 20 (2010)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 19 (2009)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 18 (2008)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 17 (2007)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 16 (2006)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 15 (2005)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 13 (2003)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 12 (2002)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 11 (2001)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 10 (2000)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 9 (1999)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8 (1998)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8, number 1 (1998)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8, number 2 (1998)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8, number 3 (1998)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8, number 4 (1998)
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- Source identification in distributed parameter systems
- The Heisenberg modelling procedure and applications to process control
- Contribution plots: A missing link in multivariate quality control
- Nonlinear black-box identification of distillation column models - design variable selection for model performance enhancement
- Issues in nonlinear parameter estimation and multivariate model discrimination: Applications in polymer reaction engineering
- Lake bed classification using acoustic data
- Neural network signal interpretation for optimization of chromatographic protein purifications
- System modelling using neural network parameter functions
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 8, number 1 (1998)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 7 (1997)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 6 (1996)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 5 (1995)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 4 (1994)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 3 (1993)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 2 (1992)
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International Journal of Applied Mathematics and Computer Science (AMCS),volume 1 (1991)
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International Journal of Applied Mathematics and Computer Science (AMCS), volume 26 (2016)
| Edition name | Date |
|---|---|
| Neural network signal interpretation for optimization of chromatographic protein purifications | Sep 3, 2021 |
