Object
Title: Rheology of drugs for topical and transdermal delivery
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Abstract:
Skin drug delivery systems are a constant source of interest because of the benefits that they offer to overcome many drawbacks associated with other modes of drug delivery (i.e. oral, intravenous, etc.). Because of the impermeable nature of the skin, designing a suitable drug delivery vehicle that penetrates the skin barrier is challenging. ; Skin drug delivery can be subdivided into topical and transdermal (Fig.1). In a topical administration the drug is intended to act at skin level, this is indicated for the treatment of skin diseases. The aim of transdermal administration is getting a systemic release and in this case the skin represents a barrier not a target. The availability of drugs or other active substances through the skin depends basically on two consecutive steps: the release of these drugs or substances from vehicle or carrier and their subsequent permeation through the skin. Hence, studies on the specific properties of vehicles or carriers, such as their rheological behaviours, are of great interest in the field of pharmaceutical products. ; The objective of the present study is to systematically characterize a nonlinear rheological behaviour and flow properties of drugs and drug carriers into topical and transdermal administration. To this aim, one- and three-dimensional rheological models are presented, which may be used to describe drug release through the skin and through the extracellular and interstitial matrix structures. Finally, the rheological measurements of some commercial creams and ointments were made.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
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Pages:
Source:
IJAME, volume 24, number 1 (2019)
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License:
License CC BY-NC-ND 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Digital Library of Zielona Góra > Repository > Faculties > Faculty of Mechanical Engineering
- Digital Library of Zielona Góra > Repository > Types of work > Articles
- Digital Library of Zielona Góra > Repository > Scientific journals and UZ publishing series > International Journal of Applied Mechanics and Engineering (IJAME) > International Journal of Applied Mechanics and Engineering (IJAME) (2019)
Last modified:
Jul 6, 2023
In our library since:
Mar 1, 2023
Number of object content hits:
147
All available object's versions:
https://zbc.uz.zgora.pl/publication/78251
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International Journal of Applied Mechanics and Engineering (IJAME)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 26 (2021)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 25 (2020)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 1 (2019)
- International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 1 (2019) - spis treści
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 2 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 3 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 4 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24, number 1 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 22 (2017)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 21 (2016)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 20 (2015)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 19 (2014)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 18 (2013)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
| Edition name | Date |
|---|---|
| Rheology of drugs for topical and transdermal delivery | Jul 6, 2023 |
