Obiekt
Tytuł: Drug diffusion transport through human skin
Współtwórca:
Tytuł publikacji grupowej:
Abstract:
The stratum corneum (SC) forms the outermost layer of the human skin and is essentially a multilamellar lipid milieu punctuated by protein-filled corneocytes that augment membrane integrity and significantly increase membrane tortuosity. The lipophilic character of the SC, coupled with its intrinsic tortuosity, ensure that it almost always provides the principal barrier to the entry of drug molecules into the organism. ; Drugs can be administered either as suspensions or as solutions and the formulation can range in complexity from a gel or and ointment to a multilayer transdermal path. In this paper, we discuss theoretical principles used to describe transdermal release and we show that relatively simple membrane transport models based on the appropriate solution to the Fick`s second law of diffusion can be used to explain drug release kinetics into such a complex biological membrane as the human skin. ; To apply the Fick`s law we introduced into our considerations a brick-and-mortar model with two factors of tortuosity. Assuming that the mortar thickness is variable we also introduced the hindrance factor allowing us to model this variability. Having the modified Fick`s equation we presented its general solution and two special cases of this solution frequently applicable in permeation experiments. It seems that the solutions presented herein better approximate the real conditions of drug delivery then these well known.
Wydawca:
Zielona Góra: Uniwersytet Zielonogórski
Format:
Identyfikator zasobu:
DOI:
Strony:
Źródło:
IJAME, volume 23, number 4 (2018)
Jezyk:
Licencja:
Licencja CC BY-NC-ND 4.0:
Prawa do dysponowania publikacją:
Biblioteka Uniwersytetu Zielonogórskiego
Kolekcje, do których przypisany jest obiekt:
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Jednostki organizacyjne > Wydział Mechaniczny
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Typy utworów > Artykuły
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Czasopisma naukowe i serie wydawnicze UZ > International Journal of Applied Mechanics and Engineering (IJAME)
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Czasopisma naukowe i serie wydawnicze UZ > International Journal of Applied Mechanics and Engineering (IJAME) > International Journal of Applied Mechanics and Engineering (IJAME) (2018)
Data ostatniej modyfikacji:
2023-07-06
Data dodania obiektu:
2023-04-04
Liczba wyświetleń treści obiektu:
105
Wszystkie dostępne wersje tego obiektu:
https://zbc.uz.zgora.pl/publication/80193
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Wyświetl opis w formacie OAI-PMH:
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International Journal of Applied Mechanics and Engineering (IJAME)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 28 (2023)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 27 (2022)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 26 (2021)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 25 (2020)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 2 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 3 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018)
- International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018) - Contents
- Calculation method for plates with discrete variable thickness under uniform loading or hydrostatic pressure
- Effects of heat and mass flux on MHD free convection flow through a porous medium with radiation and first order chemical reaction
- A study on vibration of tapered non-homogeneous rectangular plate with structural parameters
- Numerical studies of nonlinear gearing models using bond graph method
- Thermal disturbances in twinned orthotropic thermoelastic material
- Linear stability effect of densely distributed porous medium and Coriolis force on Soret driven ferrothermohaline convection
- Propagation of torsional surface waves in a non-homogeneous half-space with circular irregularity in free surface
- Study on harmonic analysis of functionally graded plates using FEM
- Double-diffusive convection of synovial (couple-stress) fluid in the presence of hall current through a porous medium
- Drug diffusion transport through human skin
- Fractal model of transdermal drug delivery
- Boundary layer analysis in nanofluid flow past a permeable moving wedge in presence of magnetic field by using falkner - skan model
- An analysis of relations for determining the thermal conductivity of rigid polymer foams
- Decision of the direct position problem of the joint relative manipulation mechanism with five degrees of freedom
- Buckling analysis of airframe jointed panel under combined loading
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 22 (2017)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 21 (2016)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 20 (2015)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 19 (2014)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 18 (2013)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
| Nazwa wydania | Data |
|---|---|
| Drug diffusion transport through human skin | 2023-07-06 |
