Obiekt
Tytuł: Fractal model of transdermal drug delivery
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Tytuł publikacji grupowej:
Abstract:
Skin, separating the vital organs of a human body, is a desirable route for drug delivery. However, the intact skin is normally permeable only for drug molecules with a low molecular weight. The stratum corneum (SC), being the outermost layer of the skin and the epidermis being the second - more permeable - layer of the skin, play an essential function in transdermal drug delivery. Physical and chemical methods of skin poration are used to enhance transdermal drug delivery. ; Each poration leads to an irregular system of pores which are connected with a system of micro-capillaries passing through the epidermis. Both the systems by their irregularity form a fractal porous matrix. Drugs administrated by this matrix can be either suspensions and solutions or creams and gels, therefore they have to be modelled as non-Newtonian fluids. To analyse the fluid flow through the porous matrix the model of the epidermis is assumed as gobbet-and-mortar with the tortuous mortar of variable thickness and after transition from the mortar to the tube one considered classical and fractal capillary flows of selected non-Newtonian fluids. ; Fractal expressions for the flow rate, velocity and permeability of fluids flow in a porous matrix are derived based on the fractal properties of the epidermis and capillary model. Each parameter in the proposed expressions does not contain any empirical constant and has a clear physical meaning and the proposed fractal models relate the flow properties of considered fluids with the structural parameters of the epidermis as a porous medium. The presented analytical expressions will help understand some of the physical principles of transdermal drug delivery.
Wydawca:
Zielona Góra: Uniwersytet Zielonogórski
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Identyfikator zasobu:
DOI:
Strony:
Źródło:
IJAME, volume 23, number 4 (2018)
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Licencja:
Licencja CC BY-NC-ND 4.0:
Prawa do dysponowania publikacją:
Biblioteka Uniwersytetu Zielonogórskiego
Kolekcje, do których przypisany jest obiekt:
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Jednostki organizacyjne > Wydział Mechaniczny
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Typy utworów > Artykuły
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Czasopisma naukowe i serie wydawnicze UZ > International Journal of Applied Mechanics and Engineering (IJAME)
- Zielonogórska Biblioteka Cyfrowa > Repozytorium > Czasopisma naukowe i serie wydawnicze UZ > International Journal of Applied Mechanics and Engineering (IJAME) > International Journal of Applied Mechanics and Engineering (IJAME) (2018)
Data ostatniej modyfikacji:
2023-07-06
Data dodania obiektu:
2023-04-04
Liczba wyświetleń treści obiektu:
80
Wszystkie dostępne wersje tego obiektu:
https://zbc.uz.zgora.pl/publication/80194
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Wyświetl opis w formacie OAI-PMH:
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International Journal of Applied Mechanics and Engineering (IJAME)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 28 (2023)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 27 (2022)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 26 (2021)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 25 (2020)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 2 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 3 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018)
- International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018) - Contents
- Calculation method for plates with discrete variable thickness under uniform loading or hydrostatic pressure
- Effects of heat and mass flux on MHD free convection flow through a porous medium with radiation and first order chemical reaction
- A study on vibration of tapered non-homogeneous rectangular plate with structural parameters
- Numerical studies of nonlinear gearing models using bond graph method
- Thermal disturbances in twinned orthotropic thermoelastic material
- Linear stability effect of densely distributed porous medium and Coriolis force on Soret driven ferrothermohaline convection
- Propagation of torsional surface waves in a non-homogeneous half-space with circular irregularity in free surface
- Study on harmonic analysis of functionally graded plates using FEM
- Double-diffusive convection of synovial (couple-stress) fluid in the presence of hall current through a porous medium
- Drug diffusion transport through human skin
- Fractal model of transdermal drug delivery
- Boundary layer analysis in nanofluid flow past a permeable moving wedge in presence of magnetic field by using falkner - skan model
- An analysis of relations for determining the thermal conductivity of rigid polymer foams
- Decision of the direct position problem of the joint relative manipulation mechanism with five degrees of freedom
- Buckling analysis of airframe jointed panel under combined loading
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 22 (2017)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 21 (2016)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 20 (2015)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 19 (2014)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 18 (2013)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 29 (2024)
| Nazwa wydania | Data |
|---|---|
| Fractal model of transdermal drug delivery | 2023-07-06 |
