Object
Title: Fractal model of transdermal drug delivery
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Abstract:
Skin, separating the vital organs of a human body, is a desirable route for drug delivery. However, the intact skin is normally permeable only for drug molecules with a low molecular weight. The stratum corneum (SC), being the outermost layer of the skin and the epidermis being the second - more permeable - layer of the skin, play an essential function in transdermal drug delivery. Physical and chemical methods of skin poration are used to enhance transdermal drug delivery. ; Each poration leads to an irregular system of pores which are connected with a system of micro-capillaries passing through the epidermis. Both the systems by their irregularity form a fractal porous matrix. Drugs administrated by this matrix can be either suspensions and solutions or creams and gels, therefore they have to be modelled as non-Newtonian fluids. To analyse the fluid flow through the porous matrix the model of the epidermis is assumed as gobbet-and-mortar with the tortuous mortar of variable thickness and after transition from the mortar to the tube one considered classical and fractal capillary flows of selected non-Newtonian fluids. ; Fractal expressions for the flow rate, velocity and permeability of fluids flow in a porous matrix are derived based on the fractal properties of the epidermis and capillary model. Each parameter in the proposed expressions does not contain any empirical constant and has a clear physical meaning and the proposed fractal models relate the flow properties of considered fluids with the structural parameters of the epidermis as a porous medium. The presented analytical expressions will help understand some of the physical principles of transdermal drug delivery.
Publisher:
Zielona Góra: Uniwersytet Zielonogórski
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Source:
IJAME, volume 23, number 4 (2018)
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License CC BY-NC-ND 4.0:
Rights:
Biblioteka Uniwersytetu Zielonogórskiego
Object collections:
- Digital Library of Zielona Góra > Repository > Faculties > Faculty of Mechanical Engineering
- Digital Library of Zielona Góra > Repository > Types of work > Articles
- Digital Library of Zielona Góra > Repository > Scientific journals and UZ publishing series > International Journal of Applied Mechanics and Engineering (IJAME)
- Digital Library of Zielona Góra > Repository > Scientific journals and UZ publishing series > International Journal of Applied Mechanics and Engineering (IJAME) > International Journal of Applied Mechanics and Engineering (IJAME) (2018)
Last modified:
Jul 6, 2023
In our library since:
Apr 4, 2023
Number of object content hits:
75
All available object's versions:
https://zbc.uz.zgora.pl/publication/80194
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International Journal of Applied Mechanics and Engineering (IJAME)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 24 (2019)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 1 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 2 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 3 (2018)
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International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018)
- International Journal of Applied Mechanics and Engineering (IJAME), volume 23, number 4 (2018) - spis treści
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| Edition name | Date |
|---|---|
| Fractal model of transdermal drug delivery | Jul 6, 2023 |
